{"product_id":"alzheimers-disease-alz","title":"ALZHEIMER'S DISEASE (ALZ)","description":"\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eKIT CONTENTS:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAlzheimer’s Disease (AD) Nosode\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMicroglia\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eUnique brain macrophage-like cells, and one type of glial cell, responsible for “elimination of microbes, dead cells, redundant synapses, protein aggregates” and other particulates that may endanger the CNS\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCD33 gene \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eGene that encodes for microglia and its ‘on-off’ switch\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTREM2 gene \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn the brain, TREM2 gene (triggering receptor expressed on myeloid cells-2) is exclusively expressed by microglia. TREM2 are cell surface transmembrane glycoproteins. Research suggests that TREM2 glycoproteins modulate inflammatory signaling helping to regulate microglia.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eOligodendrocyte\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA glial cell that creates myelin sheath, provides support to axons of neurons in the brain and CNS\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAstrocyte\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA star shaped glial cell. Astrocytes are the most numerous cell type within the central nervous system (CNS) and perform a variety of tasks, from\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eaxon guidance and synaptic support, to the control of the blood brain barrier and blood flow.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eEpendymocyte\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCiliated-epithelial glial cell. \u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eplay a critical role in cerebrospinal fluid (CSF) homeostasis, brain metabolism, and the clearance of waste from the brain.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAmyloid Beta peptide\u003c\/strong\u003e\u003cstrong data-mce-fragment=\"1\"\u003e \/ Aβ\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAmyloid beta\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003epeptide is generated from the sequential cleavage of amyloid A4 protein precursor  (APP). Amyloid Beta protein is the main component of amyloid plaques in the brains of those with AD.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAmyloid beta precursor protein \/ APP\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAPP \/ Amyloid protein precursor gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAmyloid plaques\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAggregation of Amyloid beta protein fibrils in the brain are described as plaques\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePSEN1 \/ Presenilin 1 gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eProtein coding gene implicated in early onset AD\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePSEN2 \/ Presenilin 2 gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eProtein coding gene implicated in early onset AD\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAPOE4 \/ Apolipoprotein E4 gene\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAPOE4 \/A\u003c\/strong\u003e\u003cstrong data-mce-fragment=\"1\"\u003epolipoprotein\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAPOE4 is a key protein involved in lipid metabolism. It also helps regulate the aggregation and metabolism of amyloid protein.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeuroinflammation \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eActivation of the brain's innate immune system in response to an inflammatory challenge\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand is characterized by a host of cellular and molecular changes within the brain. Microglia play a key role in creating neuroinflammation.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eT-Tau \/ Total tau\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTau is a neuronal microtubule-associated protein (MAP) that is involved in the regulation of axonal microtubule assembly. It is a phosphorylated protein. Tau ‘tangles’ in neurons is a characteristic of AD.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eP-Tau \/ phosphorylated tau \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTau is a phosphorylated protein,\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003econtaining 85 potential serine (S), threonine (T), and tyrosine (Y) phosphorylation sites. Phosphorylation is\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ethe chemical addition of a phosphoryl group (PO\u003csub data-mce-fragment=\"1\"\u003e3\u003c\/sub\u003e\u003csup data-mce-fragment=\"1\"\u003e-\u003c\/sup\u003e) to an organic molecule. The removal of a phosphoryl group is called dephosphorylation. Both phosphorylation and dephosphorylation are carried out by enzymes (e.g., kinases, phosphotransferases).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e“Tau is a protein with intrinsically disordered regions (IDRs), and so interacts with many other partners in addition to microtubules. Phosphorylation at selected sites modulates tau’s various intracellular interactions and regulates the properties of IDRs. In Alzheimer’s disease (AD) and other tauopathies, tau exhibits pathologically increased phosphorylation (hyperphosphorylation) at selected sites and aggregates into neurofibrillary tangles (NFTs).\u003cspan data-mce-fragment=\"1\"\u003e” LINK: https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2019.00256\/full\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHyperphosphorylated Tau\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTau Kinases\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTau buildup is caused by increased activity of enzymes that act on tau called tau kinases, which cause the tau protein to misfold and clump, forming neurofibrillary tangles\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeurofibrillary tangles \/NFTs\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eBlood brain barrier\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eBrain limbic \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eBrain cortex\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eBrain reptilian\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeuron\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeuronal dendrite\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeuronal synapse\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAluminum\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSilicon\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuantity: 30 Vials\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eModel: ALZ\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #dc3535;\"\u003eNote: \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cspan style=\"color: #dc3535;\"\u003eErgopathics test kits are not intended to diagnose, prevent, treat or cure any disease, disorder or abnormal physical state.  The vials contain ethanol and water and the process used to imprint them with electromagnetic signatures has not been tested or validated by any scientific method and is not approved by any regulatory authority. They are intended for use solely by qualified providers to support wellness and manage stress\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e","brand":"Ergopathics","offers":[{"title":"30 Vials","offer_id":67828686192831,"sku":"wom1793414662941","price":75.24,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0753\/0545\/1711\/files\/alzheimers-disease-alz_1.jpg?v=1793414668","url":"https:\/\/aliburr.shop\/products\/alzheimers-disease-alz","provider":"My Store","version":"1.0","type":"link"}